SCIENCE HUB · GENOME, RNA & CHROMATIN BIOLOGY
A Genome Has to Be Copied, Read, Packaged, Repaired and Reinterpreted Without Losing the Difference Between Information and Damage.
This corridor follows DNA, chromosomes, chromatin and RNA from molecular recognition to faithful inheritance, regulated expression, surveillance, translation and repair.
DNA Replication, Recombination and Repair
- Eukaryotic DNA Replication Licensing
- Eukaryotic DNA Replication Termination
- Human Mitochondrial DNA Replication
- Eukaryotic Base Excision Repair
- Eukaryotic Nucleotide Excision Repair
- Bacterial Nucleotide Excision Repair
- Eukaryotic DNA Mismatch Repair
- Bacterial DNA Mismatch Repair
- Eukaryotic Translesion DNA Synthesis
- RAD51–BRCA Homologous Recombination
- RecA Homologous Recombination and the Bacterial SOS Response
- Eukaryotic Non-Homologous End Joining
- Fanconi Anaemia Interstrand-Crosslink Repair
- DNA–Protein Crosslink Repair
- R-Loops and Genome Stability
- Telomeres, Telomerase and Shelterin
- Synaptonemal Complex and Meiotic Recombination
Chromosomes, Chromatin and Nuclear Organisation
- Cohesin and CTCF Loop Extrusion
- Histone Chaperones and Nucleosome Assembly
- BAF/SWI–SNF Chromatin Remodelling
- Nuclear Speckles and RNA-Processing Organisation
- Nuclear Lamina, Genome Organisation and Mechanics
- Archaeal Histones and Chromatin
- Bacterial SMC Condensins and Chromosome Architecture
- DNA Supercoiling and Bacterial Topoisomerases
RNA Processing, Editing and Surveillance
- Eukaryotic mRNA 3′-End Processing, Polyadenylation and Termination
- mRNA 3′-End Processing and Alternative Polyadenylation
- The Spliceosome Catalytic Cycle
- MicroRNA Biogenesis and RISC Silencing
- ADAR A-to-I RNA Editing
- Nonsense-Mediated mRNA Decay
- Eukaryotic RNA Exosome and Nuclear Surveillance
- Human Mitochondrial RNA Processing
- Bacterial RNA Degradosome
- RNA Thermometers
- Riboswitches and Metabolite-Sensing RNA
Ribosomes, Translation and Protein-Coding Fidelity
- Eukaryotic Ribosome Biogenesis
- Bacterial Ribosome Biogenesis
- Eukaryotic Translation Initiation
- Human Mitochondrial Translation
- Eukaryotic tRNA Modifications and Wobble Decoding
- Ribosome-Associated Quality Control
- tmRNA–SmpB Trans-Translation and Ribosome Rescue
- Bacterial Ribosome Hibernation
- Selenoproteins and Selenocysteine Recoding
- Inteins and Protein Splicing
Spider / Web / Hidden / Deep Connections
Open the Science Connection Map →
- Spider — candidates: Physiology & Mechanobiology and Instrumentation become candidates when genome state depends on force, nuclear architecture, spatial organisation or how DNA/RNA state was measured.
- Web — admitted: Molecular & Cellular Biology · Microbiology · Biology · Research.
- Hidden Connect: information has physical organisation. Chromatin packing, nuclear lamina, loop extrusion, condensates and mechanical state connect genome regulation to mechanobiology without reducing genetic regulation to force alone.
- Deep Connect: Genome/RNA → Molecular Cell → Physiology → Instrumentation.
