Category: Blog
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How to Learn Protein N-Myristoylation: From NMT1/NMT2 and Myristoyl-CoA to Membrane Targeting, Myristoyl Switches and Lipidation Proteomics
Quick Read. N-myristoylation is a lipid modification that attaches a 14-carbon myristoyl group to selected proteins, usually at an exposed N-terminal glycine. The modification is installed by N-myristoyltransferases NMT1 and NMT2 using myristoyl-CoA. It often helps proteins associate with membranes, but the important idea is not “fat makes proteins sticky.” Myristate is one part of…
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How to Learn Protein Prenylation and CaaX Processing: From FPP/GGPP to FTase/GGTase, RCE1–ICMT, Rab Escort and Membrane Targeting
Learn protein prenylation from FPP/GGPP and CaaX recognition through FTase/GGTase, RCE1–ICMT processing, Rab escort, dynamic membrane targeting, evidence, misconceptions and model limits.
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How to Learn O-GlcNAc Cycling: From Hexosamine Flux and UDP-GlcNAc to OGT–OGA, Signal Integration, Proteomics and Stress Adaptation
Learn O-GlcNAc cycling from hexosamine-pathway flux and UDP-GlcNAc to OGT/OGA substrate selection, signalling, stress adaptation, proteomic measurement, misconceptions and model limits.
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How to Learn Mitochondrial Protein Lipoylation: From mtFAS and LIPT2 to LIAS–LIPT1, Swinging Lipoyl Arms and Oxidative Metabolism
Learn mitochondrial protein lipoylation from mtFAS-derived octanoyl precursor through LIPT2, GCSH, LIAS and LIPT1 to swinging-arm catalysis, metabolic flux, evidence, misconceptions and current 2026 findings.
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How to Learn DNA–Protein Crosslink Repair: From Covalent DNA Adducts to SPRTN Proteolysis, Proteasome Backup, TDP Enzymes and Replication Restart
Learn DNA–protein crosslink repair as a distinct genome-maintenance problem, from covalent protein obstacles and ubiquitin-gated SPRTN/proteasome proteolysis to TDP bond chemistry, replication restart, evidence, misconceptions and model limits.
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How to Learn the Fanconi Anemia DNA Interstrand Crosslink Repair Pathway: From FANCM Sensing to FANCD2–FANCI Ubiquitination, Unhooking, TLS and Homologous Recombination
Learn the Fanconi interstrand-crosslink repair pathway from stalled replication forks and FANCD2–FANCI monoubiquitination to nuclease unhooking, translesion synthesis, homologous recombination, endogenous aldehydes, evidence and model limits.
